«The fact that we find it difficult to give precise definition of complex phenomena does not mean that they do not exist».
Life arises, evolves in line with the principle of substance stability. The transition of the chemical evolution into the biological evolution is a gradual. It is primarily associated with the pursuit of the specific Gibbs function of the formation of supramolecular structure of relatively large local systems* to a minimum. These local systems contain different molecules or fragments of molecules, in which are set a local quasi-equilibrium. In this case it is advisable to talk about the supramolecular thermodynamic mechanisms of interaction between the different sub-hierarchies of supramolecular structures. It seems more accurate to discuss the mechanisms of supramolecular renewing primary areas of living systems. These areas may contain fragments of "primary" nucleic structures, peptides, sugars, lipids and other molecules. It is advisable to talk about the totality of the molecular and supramolecular transformations in local areas, and not only to discuss the chemical reactions of individual molecules. The question of what type of molecules appeared first (RNA, DNA, peptides, lipids, etc.) is not a complete. Primary molecules and fragments of these molecules, or their precursors, appeared on Earth (or other celestial bodies), almost at the same time. These primary fragments and molecular structures were be selected by the supramolecular thermodynamics in accordance with the principle of substance stability. It was the beginning of biological evolution.